7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

Base Information

Chemical Name:7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one
CAS No.:272120-82-8
Molecular Formula:C₁₉H₁₇ClN₄O₃
Molecular Weight:384.822
Hs Code.:

Synonyms:7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

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Chemical Property of 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

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Technology Process of 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

There total 5 articles about 7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 19097-44-0
4-iodobutylbenzoate

: 272120-79-3
4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

: 272120-82-8
7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h;
DOI:10.1002/jhet.5570370102

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 272120-82-8
7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / potassium nitrate; conc. sulfuric acid / 8 h / 110 °C

2.1: 91 percent / water; ammonium chloride; iron / CHCl₃ / 9 h / Heating

3.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

3.2: 91 percent / tetrahydrofuran / 5 h / 50 - 60 °C

4.1: tert-butylnitrite / dimethylformamide / 1 h / 50 - 60 °C

4.2: 33 percent / 50 percent aq. hypophosphorous acid / dimethylformamide / 1 h / 20 °C

5.1: 74 percent / potassium carbonate / dimethylformamide / 21 h / 20 °C

With tert.-butylnitrite; sulfuric acid; ammonium chloride; water; iron; sodium hydride; potassium carbonate; potassium nitrate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1.1: Nitration / 2.1: Reduction / 3.1: Metallation / 3.2: Cyclization / 4.1: Diazotization / 4.2: Deamination / 5.1: Alkylation;
DOI:10.1002/jhet.5570370102

Reference yield:

: 25717-64-0
6-amino-4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 272120-82-8
7-(4-benzoyloxybutyl)-4-chloro-5-cyano-2-methyl-7H-pyrrolo[2,3-c]pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

1.2: 91 percent / tetrahydrofuran / 5 h / 50 - 60 °C

2.1: tert-butylnitrite / dimethylformamide / 1 h / 50 - 60 °C

2.2: 33 percent / 50 percent aq. hypophosphorous acid / dimethylformamide / 1 h / 20 °C

3.1: 74 percent / potassium carbonate / dimethylformamide / 21 h / 20 °C

With tert.-butylnitrite; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Cyclization / 2.1: Diazotization / 2.2: Deamination / 3.1: Alkylation;
DOI:10.1002/jhet.5570370102