1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

Base Information

Chemical Name:1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol
CAS No.:208763-43-3
Molecular Formula:C₁₂H₁₈O₃
Molecular Weight:210.273
Hs Code.:

Synonyms:1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

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Chemical Property of 1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

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Technology Process of 1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

There total 8 articles about 1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 208763-42-2
1-(2-Hydroxy-5-methyl-phenyl)-1-isopropylsulfanyl-3-methyl-butane-2,3-diol

: 208763-43-3
1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

Guidance literature:: With Raney Ni(W₄); In ethanol; for 0.75h; Ambient temperature;
DOI:10.1055/s-1998-1751

Reference yield:

: 115-18-4
2-methyl-3-buten-2-ol

: 208763-43-3
1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOOH / VO(acac)2 / CH₂Cl₂ / 5 h / Ambient temperature

2: NaH / CH₂Cl₂ / 24 h / Ambient temperature

3: 79 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 80 percent / SO₂Cl₂, s-collidine, Et₃N / CH₂Cl₂ / -50 °C

5: 62 percent / LiAlH₄ / diethyl ether / 12 h / Ambient temperature

6: 82 percent / Raney Ni(W₄) / ethanol / 0.75 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; tert.-butylhydroperoxide; lithium aluminium tetrahydride; sulfuryl dichloride; Raney Ni(W₄); sodium hydride; triethylamine; bis(acetylacetonate)oxovanadium; In diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-1998-1751

Reference yield:

: 556-82-1
3-methyl-2-buten-1-ol

: 208763-43-3
1-(2-Hydroxy-5-methyl-phenyl)-3-methyl-butane-2,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOOH / VO(acac)2 / CH₂Cl₂ / 5 h / Ambient temperature

2: NaOH / 2-methyl-propan-2-ol; ethanol / 12 h / Ambient temperature

3: 79 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 80 percent / SO₂Cl₂, s-collidine, Et₃N / CH₂Cl₂ / -50 °C

5: 62 percent / LiAlH₄ / diethyl ether / 12 h / Ambient temperature

6: 82 percent / Raney Ni(W₄) / ethanol / 0.75 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; tert.-butylhydroperoxide; sodium hydroxide; lithium aluminium tetrahydride; sulfuryl dichloride; Raney Ni(W₄); triethylamine; bis(acetylacetonate)oxovanadium; In diethyl ether; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1055/s-1998-1751