(S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate

Base Information

• Chemical Name: (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate
• CAS No.: 192565-63-2
• Molecular Formula: C₁₅H₁₇NO₃S
• Molecular Weight: 291.371
• Mol file: 192565-63-2.mol

Synonyms:(S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate

Chemical Property of (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate

There total 3 articles about (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethylthio-1-(trimethylsiloxy)ethene (63584-41-8) + 2-furfurylideneamino-phenol (6078-02-0) → (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate (192565-63-2) + S-ethyl (R)-3-(2-furyl)-3-[(2-hydroxyphenyl)amino]propanethioate

Guidance literature:

With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; Nb(OMe)5; In dichloromethane; toluene; at -10 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1002/anie.200462204

Reference yield:

furfural (98-01-1) → (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate (192565-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂; dimethylformamide / 20 °C

2: (R)-3-(2-OH-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; N-methylimidazole; molecular sieves 3 Angstroem / Nb(OMe)5 / toluene; CH₂Cl₂ / 48 h / -10 °C

With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; 4 A molecular sieve; Nb(OMe)5; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.200462204

Reference yield:

2-amino-phenol (95-55-6) → (S)-S-ethyl 3-(2'-furyl)-3-[(2'-hydroxyphenyl)amino]propanethioate (192565-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂; dimethylformamide / 20 °C

2: (R)-3-(2-OH-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; N-methylimidazole; molecular sieves 3 Angstroem / Nb(OMe)5 / toluene; CH₂Cl₂ / 48 h / -10 °C

With (R)-3-(2-hydroxy-3-isopropylbenzyl)-1,1'-binaphthalene-2,2'-diol; 1-methyl-1H-imidazole; 3 A molecular sieve; 4 A molecular sieve; Nb(OMe)5; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.200462204

upstream raw materials:

1-ethylthio-1-(trimethylsiloxy)ethene

2-furfurylideneamino-phenol

furfural

2-amino-phenol