N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

Base Information

Chemical Name:N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine
CAS No.:199108-91-3
Molecular Formula:C₂₅H₃₀ClNO₂
Molecular Weight:411.972
Hs Code.:

Synonyms:N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

Chemical Property:

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Technology Process of N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

There total 4 articles about N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 199108-79-7
N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(2S)-pyrrolidine-2-methanol

: 199108-91-3
N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

Guidance literature:: With thionyl chloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm980549x

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 199108-91-3
N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 10 h / Ambient temperature

2: 95 percent / SOCl₂ / CH₂Cl₂ / 5 h / Ambient temperature

With thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980549x

Reference yield:

: 199109-42-7
5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-methylchloride

: 199108-91-3
N-(5-benzyloxy-2,4,6,7-tetramethylbenzofuran-3-ylmethyl)-(3R)-chloropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 10 h / Ambient temperature

2: 95 percent / SOCl₂ / CH₂Cl₂ / 5 h / Ambient temperature

With thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980549x