Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid

Base Information

• Chemical Name: Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid
• CAS No.: 906077-49-4
• Molecular Formula: C₁₅H₁₂F₃NO₂
• Molecular Weight: 295.261
• Mol file: 906077-49-4.mol

Synonyms:Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid

Chemical Property of Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid

There total 6 articles about Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

phenylamino-(4-trifluoromethyl-phenyl)-acetic acid methyl ester (1210859-17-8) → Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid (906077-49-4)

Guidance literature:

phenylamino-(4-trifluoromethyl-phenyl)-acetic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 80 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=2;

Reference yield: 22.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + 2-oxo-propionic acid (127-17-3) + aniline (62-53-3) → Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid (906077-49-4)

Guidance literature:

4-Trifluoromethylbenzaldehyde; aniline; In methanol; at 20 ℃; for 0.166667h;

2-oxo-propionic acid; With Cyclohexyl isocyanide; In methanol; at 20 ℃; for 48h;

With potassium hydroxide; In methanol; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.1c00821

Reference yield:

4-Trifluoromethylphenylacetic acid (32857-62-8) → Phenylamino-(4-trifluoromethyl-phenyl)-acetic acid (906077-49-4)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 16 h / 20 °C

2: N-Bromosuccinimide; hydrogen bromide / water; tetrachloromethane / 2 h / Reflux

3: acetonitrile / 16 h / Reflux

4: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; water; hydrogen bromide; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; water; acetonitrile;

DOI:10.1016/j.bmcl.2013.01.062

upstream raw materials:

phenylamino-(4-trifluoromethyl-phenyl)-acetic acid methyl ester

4-Trifluoromethylphenylacetic acid

methyl 2-(4-(trifluoromethyl)phenyl)acetate

α-bromo-(4-(trifluoromethyl)phenyl)acetic acid methyl ester

Downstream raw materials:

N-[2-(2-Chloro-phenyl)-pyrrolidin-1-yl]-2-phenylamino-2-(4-trifluoromethyl-phenyl)-acetamide

C₂₅H₂₂ClF₃N₂O

C₂₅H₂₂ClF₃N₂O