(R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

Base Information

Chemical Name:(R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate
CAS No.:1623145-56-1
Molecular Formula:C₂₁H₁₇F₃O₄
Molecular Weight:390.359
Hs Code.:

Synonyms:(R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

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Technology Process of (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

There total 2 articles about (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 5369-55-1
2,4-diphenylfuran

: 1623145-56-1
(R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

Guidance literature:: With C₄₄H₃₂P₂Pd⁽²⁺⁾*2F₆Sb^(1-); In diethyl ether; dichloromethane; at -78 ℃; for 8h; stereoselective reaction;
DOI:10.1016/j.tetasy.2014.06.013

Reference yield: 62.0%

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 102705-79-3
1,2,4-triphenylbut-3-yne-1,2-diol

: 1623145-56-1
(R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate

Guidance literature:: 1,2,4-triphenylbut-3-yne-1,2-diol; With silver hexafluoroantimonate; C₁₈H₂₈AuCl₂P₂; In dichloromethane; at 20 ℃; for 1h;

ethyl-3,3,3-trifluoropyruvate; With PdCl₂[(S)-BINAP]; silver hexafluoroantimonate; In diethyl ether; dichloromethane; at -40 ℃; for 16h; stereoselective reaction;
DOI:10.1016/j.tetasy.2014.06.013