2,4-Diphenylfuran

Base Information

• Chemical Name: 2,4-Diphenylfuran
• CAS No.: 5369-55-1
• Molecular Formula: C16H12O
• Molecular Weight: 220.271
• NSC Number: 402159
• DSSTox Substance ID: DTXSID70322847
• Nikkaji Number: J372.470K
• Wikidata: Q27122079
• Metabolomics Workbench ID: 57433
• Mol file: 5369-55-1.mol

Synonyms:2,4-diphenylfuran;2,4-diphenyl-furan;5369-55-1;NSC 402159;NSC402159;SCHEMBL674221;CHEBI:50461;UQJDIUAEJBVXMV-UHFFFAOYSA-;DTXSID70322847;AKOS015906518;NSC-402159;Q27122079

Chemical Property of 2,4-Diphenylfuran

Chemical Property:

• Vapor Pressure: 8.14E-05mmHg at 25°C
• Boiling Point: 351.8°Cat760mmHg
• Flash Point: 169.9°C
• PSA: 13.14000
• Density: 1.086g/cm³
• LogP: 4.61360
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 220.088815002
• Heavy Atom Count: 17
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=CO2)C3=CC=CC=C3

Technology Process of 2,4-Diphenylfuran

There total 50 articles about 2,4-Diphenylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-diphenyl-but-3-yne-1,2-diol (58294-83-0) → 2,4-diphenylfuran (5369-55-1)

Guidance literature:

With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; at 50 ℃; for 0.25h; Reagent/catalyst; Temperature; Time; Microwave irradiation;

DOI:10.1002/chem.201203800

Reference yield: 91.0%

(3,5-Diphenyl-furan-2-yl)-phenyl-methanone (57314-28-0) → 2,4-diphenylfuran (5369-55-1)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

Reference yield: 85.0%

2-[N,N-bis(trimethylsilyloxy)amino]-3,5-diphenyl-2,3-dihydrofuran → 2,4-diphenylfuran (5369-55-1)

Guidance literature:

With ammonium fluoride; In methanol; at 0 ℃; for 0.5h;

DOI:10.1023/A:1023958806825

upstream raw materials:

dypnone

nitrobenzene

acetophenone

2,4-diphenylcrotonaldehyde

Downstream raw materials:

(Z)-1,4-diphenylbut-2-ene-1,4-dione

3,5-diphenyl-furan-2-carboxylic acid

(3,5-diphenylfuran-2-yl)trimethylsilane

C₂₃H₂₆O₄Si

Refernces

• 1、 Brovarets, Volodymyr S.,Potikha, Lyudmila M.. "Synthesis of new antineoplastic agents based on imidazo[2,1-a]pyridine". . p. 1460 - 1464. Retrieved 2020.
• 2、 Fernandes, Rushil,Mhaske, Krishna,Narayan, Rishikesh. "β-Bromoenol phosphate as a new precursor for the modular regioselective synthesis of substituted furans". . . Retrieved 2021/11/24.
• 3、 Pauli, Larissa,Tannert, Re,Scheil, Robin,Pfaltz, Andreas. "Asymmetric hydrogenation of furans and benzofurans with iridium-pyridine-phosphinite catalysts". supporting information. p. 1482 - 1487. Retrieved 2015/01/30.