4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

Base Information

Chemical Name:4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine
CAS No.:1187205-57-7
Molecular Formula:C₁₉H₁₃F₄N₃O₃
Molecular Weight:407.324
Hs Code.:

Synonyms:4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

Chemical Property:

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Technology Process of 4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

There total 2 articles about 4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1187205-75-9
4-chloro-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

: 503309-11-3
2-fluoro-4-(trifluoromethyl)phenylboronic acid

: 1187205-57-7
4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 90 ℃; Inert atmosphere;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1187205-57-7
4-(2-fluoro-4-trifluoromethylphenyl)-6-(4-methoxyphenyl)-2-methyl-5-nitropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 90 °C / Inert atmosphere

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 90 °C / Inert atmosphere

With sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane;