N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

Base Information

Chemical Name:N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate
CAS No.:77903-81-2
Molecular Formula:C₇H₇O₃S*C₁₉H₁₇N₄
Molecular Weight:472.568
Hs Code.:

Synonyms:N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

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Chemical Property of N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

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Technology Process of N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

There total 14 articles about N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6250-88-0
4,9-Dihydropyrano<3,4-b>indol-1(3H)-on

: 77903-81-2
N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / LiOH / methanol / 2 h

2: 89 percent / diethyl ether; tetrahydrofuran / 3 h

3: 95 percent / Hydrazine Hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 100 - 200 °C

4: 98.5 percent / Imidazole / dimethylformamide / 168 h

5: tert-Butylhypochlorite, Triethylamine / CH₂Cl₂ / 1 h / -78 °C

6: 74 percent / methanol / 120 h

7: 90 percent / ethyl acetate / 4 h / Ambient temperature

8: 91 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C

9: γ-Collidine / benzene / 1 h / 25 °C

10: benzene

With 1H-imidazole; 2,4,6-trimethyl-pyridine; potassium hydroxide; lithium hydroxide; 18-crown-6 ether; tert-butylhypochlorite; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; diethylene glycol; benzene;
DOI:10.1021/jo00329a029

Reference yield:

: 526-55-6,930395-07-6
2-(3-indole)-ethanol

: 77903-81-2
N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Mercuric acetate / 69 h / 25 °C

2: 70 percent / Trifluoroacetic acid / CH₂Cl₂ / 2.25 h / 15 - 18 °C

3: 67 percent / ZnCl₂ / 72 h / 105 °C

4: γ-Collidine / benzene / 1 h / 25 °C

5: benzene

With 2,4,6-trimethyl-pyridine; mercury(II) diacetate; trifluoroacetic acid; zinc(II) chloride; In dichloromethane; benzene;
DOI:10.1021/jo00329a029

Reference yield:

: 20321-71-5
2-Acetyl-3-(2-hydroxyethyl)-1H-indole

: 77903-81-2
N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-cyanopyridinium p-toluenesulfonate hemihydrate

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / Hydrazine Hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 100 - 200 °C

2: 98.5 percent / Imidazole / dimethylformamide / 168 h

3: tert-Butylhypochlorite, Triethylamine / CH₂Cl₂ / 1 h / -78 °C

4: 74 percent / methanol / 120 h

5: 90 percent / ethyl acetate / 4 h / Ambient temperature

6: 91 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C

7: γ-Collidine / benzene / 1 h / 25 °C

8: benzene

With 1H-imidazole; 2,4,6-trimethyl-pyridine; potassium hydroxide; 18-crown-6 ether; tert-butylhypochlorite; hydrazine hydrate; triethylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; diethylene glycol; benzene;
DOI:10.1021/jo00329a029