N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

Base Information

Chemical Name:N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether
CAS No.:883199-24-4
Molecular Formula:C₂₁H₁₉ClFN₃O₂
Molecular Weight:399.852
Hs Code.:

Synonyms:N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

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Chemical Property of N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

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Technology Process of N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

There total 4 articles about N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883199-21-1
N-(3-chlorophenyl)-4-iodo-2-pyridinamine

: 883199-24-4
N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / NaH / tetrahydrofuran / 3 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -75 °C

2.2: ZnCl₂ / tetrahydrofuran; hexane / -75 - 20 °C

2.3: 73 percent / Pd(PPh₃)4 / tetrahydrofuran; hexane / 1.5 h / Heating

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; 2.3: Negishi cross-coupling;
DOI:10.1016/j.tet.2005.11.067

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 883199-24-4
N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / NaH / tetrahydrofuran / 3 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -75 °C

2.2: ZnCl₂ / tetrahydrofuran; hexane / -75 - 20 °C

2.3: 73 percent / Pd(PPh₃)4 / tetrahydrofuran; hexane / 1.5 h / Heating

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; 2.3: Negishi cross-coupling;
DOI:10.1016/j.tet.2005.11.067

Reference yield:

: 108-42-9
3-chloro-aniline

: 883199-24-4
N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)carbamic acid 1,1-dimethylethyl ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: 66 percent / aq. HCl / dioxane / 46 h / Heating

2.1: 80 percent / NaH / tetrahydrofuran / 3 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -75 °C

3.2: ZnCl₂ / tetrahydrofuran; hexane / -75 - 20 °C

3.3: 73 percent / Pd(PPh₃)4 / tetrahydrofuran; hexane / 1.5 h / Heating

With hydrogenchloride; n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; hexane; 3.3: Negishi cross-coupling;
DOI:10.1016/j.tet.2005.11.067