(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

Base Information

Chemical Name:(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide
CAS No.:1068602-21-0
Molecular Formula:C₂₅H₂₉NO₂S
Molecular Weight:407.577
Hs Code.:

Synonyms:(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

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Chemical Property of (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

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Technology Process of (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

There total 1 articles about (S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2786-07-4
2-thienyl lithium

: 1068601-67-1,38735-14-7
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide

: 100-39-0
benzyl bromide

: 1068602-21-0
(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

2-thienyl lithium; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 - -40 ℃; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; formaldehyde diethyl acetal; at -40 ℃; for 6h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1068602-21-0
(S)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-(thiophen-2-yl)propanamide

: 1068602-25-4
CF₃O₃S^(1-)*C₂₅H₂₈NOS⁽¹⁺⁾

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.166667h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja806021y