(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

Base Information

Chemical Name:(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid
CAS No.:701261-74-7
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:

Synonyms:(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

Chemical Property:

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Technology Process of (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

There total 5 articles about (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 701261-91-8
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

: 701261-74-7
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; under 760 Torr;
DOI:10.1021/ja030669g

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 701261-74-7
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether

2: 0.460 g / i-Pr₂NEt / CH₂Cl₂

3: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

4: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

5: 100 percent / H₂ / Pd/C / methanol; ethyl acetate / 760 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/ja030669g

Reference yield:

: 27000-00-6
methyl 2-hydroxy-3-phenylpropionate

: 701261-74-7
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 0.460 g / i-Pr₂NEt / CH₂Cl₂

2: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

3: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

4: 100 percent / H₂ / Pd/C / methanol; ethyl acetate / 760 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja030669g