5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

Base Information

Chemical Name:5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione
CAS No.:144155-08-8
Molecular Formula:C₂₀H₁₂Cl₂F₃NO₂
Molecular Weight:426.222
Hs Code.:

Synonyms:5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

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Chemical Property of 5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

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Technology Process of 5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

There total 5 articles about 5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 144155-08-8
5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 32 percent / 50percent aq. NaOH / 72 h / Ambient temperature

2: EtONa / ethanol / 6 h / Heating

3: 2 N NaOH / 2 h / Heating

4: 5 N H₂SO₄ / 4.5 h / Heating

5: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h

With sodium hydroxide; sulfuric acid; sodium ethanolate; sodium hydride; In ethanol;
DOI:10.1021/jm00097a001

Reference yield:

: 80992-93-4
4-(4-trifluoromethylphenyl)but-3-en-2-one

: 144155-08-8
5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

Guidance literature:: Multi-step reaction with 4 steps

1: EtONa / ethanol / 6 h / Heating

2: 2 N NaOH / 2 h / Heating

3: 5 N H₂SO₄ / 4.5 h / Heating

4: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h

With sodium hydroxide; sulfuric acid; sodium ethanolate; sodium hydride; In ethanol;
DOI:10.1021/jm00097a001

Reference yield:

: Sodium; 6-ethoxycarbonyl-3-oxo-5-(4-trifluoromethyl-phenyl)-cyclohex-1-enolate

: 144155-08-8
5,7-Dichloro-3,4-dihydro-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 2 N NaOH / 2 h / Heating

2: 5 N H₂SO₄ / 4.5 h / Heating

3: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h

With sodium hydroxide; sulfuric acid; sodium hydride;
DOI:10.1021/jm00097a001