C₁₂H₈F₃NO₂

Base Information

Chemical Name:C₁₂H₈F₃NO₂
CAS No.:1352439-62-3
Molecular Formula:C₁₂H₈F₃NO₂
Molecular Weight:255.196
Hs Code.:

C<sub>12</sub>H<sub>8</sub>F<sub>3</sub>NO<sub>2</sub>

Synonyms:C₁₂H₈F₃NO₂

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Chemical Property of C₁₂H₈F₃NO₂

Chemical Property:

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Technology Process of C₁₂H₈F₃NO₂

There total 3 articles about C₁₂H₈F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1352439-45-2
C₁₂H₁₀F₃NO₂

: 1352439-62-3
C₁₂H₈F₃NO₂

Guidance literature:: With [bis(acetoxy)iodo]benzene; Rh₂(esp)2; magnesium oxide; In dichloromethane; Reflux; Inert atmosphere;
DOI:10.1021/ol203055v

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1352439-62-3
C₁₂H₈F₃NO₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h / Inert atmosphere

1.2: 18 h / 60 °C / Inert atmosphere

2.1: tetrahydrofuran; dichloromethane; water / Cooling with ice; Reflux

3.1: Rh₂(esp)2; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / Reflux; Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(acetoxy)iodo]benzene; Rh₂(esp)2; magnesium oxide; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol203055v

Reference yield:

: 77326-90-0
4-<3-(trifluoromethyl)phenyl>-3-butyn-1-ol

: 1352439-62-3
C₁₂H₈F₃NO₂

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; dichloromethane; water / Cooling with ice; Reflux

2: Rh₂(esp)2; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / Reflux; Inert atmosphere

With [bis(acetoxy)iodo]benzene; Rh₂(esp)2; magnesium oxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol203055v