77326-90-0

Upstream product

• 40365-61-5 2-(but-3-yn-1-yloxy)tetrahydropyran 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 927-74-2 3-Butyn-1-ol 
• 98-16-8 3-trifluoromethylaniline 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Downstream Products

• 1352439-45-2 C₁₂H₁₀F₃NO₂ 
• 1352439-62-3 C₁₂H₈F₃NO₂ 
• 147429-92-3 1-Methyl-4-[(E)-4-(3-trifluoromethyl-phenyl)-but-3-enyl]-piperazine 
• 147429-92-3 1-Methyl-4-[(Z)-4-(3-trifluoromethyl-phenyl)-but-3-enyl]-piperazine 
• 77318-15-1 (E)-4-bromo-1-<3-(trifluoromethyl)phenyl>-1-butene 
• 77318-14-0 (Z)-4-bromo-1-<3-(trifluoromethyl)phenyl>-1-butene 
• 77318-13-9 (E)-4-<3-(trifluoromethyl)phenyl>-3-buten-1-ol 
• 77318-12-8 (Z)-4-<3-(trifluoromethyl)phenyl>-3-buten-1-ol 

Relevant academic research and scientific papers

Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf2, an efficient Au-catalyzed cyclization-alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates.

Synthesis of propargylic and allenic carbamates via the C-H amination of alkynes

Propargylic amines are important intermediates for the synthesis of nitrogen-containing heterocycles. The insertion of a nitrene into a propargylic C-H bond has not been explored, despite the attention directed toward the Rh-catalyzed amination of other t

Coupling reactions of aryl bromides with 1-alkynols catalysed by a tetraphosphine/palladium catalyst

cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/ [PdCl(C3H5)]2 system catalyses efficiently the coupling reactions of aryl halides with a variety of alkynols such as propargyl alcohol, but-1-yn-4-ol, pent

Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists

Several alkylpiperazines, monocyclic subfragments of known tricyclic neuroleptic agents, were evaluated as dopamine antagonists in the isolated rabbit ear artery preparation. Compounds prepared and evaluated are of the general structure Ar-X-(CH2)(n)-Y, where X = C, O, and N, n = 1-3, and Y, for the most part, was 4-methylpiperazine. Those compounds where X = NH, n = 3, and X = (Z)-CH=CH, n = 2, with an electron-witdrawing group meta to the side chain, possess dopamine antagonist activity comparable to that of clozapine. It is concluded that the entire tricyclic structure of phenothiazine-like agents (or at least more than a monocyclic ring system) is necessary for optimal activity as a dopamine antagonist in the receptor preparation used in this study.