4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

Base Information

Chemical Name:4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide
CAS No.:1332760-61-8
Molecular Formula:C₂₅H₂₈F₂N₆O₂S
Molecular Weight:514.599
Hs Code.:

Synonyms:4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

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Chemical Property of 4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

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Technology Process of 4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

There total 5 articles about 4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23159-07-1
3-(1-pyrrolidinyl)propylamine

: 1332761-30-4
4-[4-cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

: 1332760-61-8
4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 218632-01-0
3-fluoro-4-nitrobenzonitrile

: 1332760-61-8
4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: ethanol; tin(II) chloride dihdyrate / 2 h / 100 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 2 h / 90 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 96 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With tin(II) chloride dihdyrate; ethanol; water; toluene-4-sulfonic acid; triethylamine; HATU; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1332760-60-7
4-[2-(3-methanesulfonylamino-1-methylpropoxy)-pyridin-3-ylamino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (3-dimethylamino-propyl)-amide

: 1332760-61-8
4-[4-Cyano-2-(2-fluoro-1-fluoromethyl-ethoxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 96 h / 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With water; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;