1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine

Base Information

• Chemical Name: 1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine
• CAS No.: 618092-82-3
• Molecular Formula: C₁₇H₁₇N₃
• Molecular Weight: 263.342
• European Community (EC) Number: 621-698-9
• ChEMBL ID: CHEMBL1371014
• Mol file: 618092-82-3.mol

Synonyms:1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine;1,3-DI-P-TOLYL-1H-PYRAZOL-5-AMINE;618092-82-3;MLS000534590;Oprea1_728592;CHEMBL1371014;HMS1917P17;HMS2338L15;STK165015;AKOS001682281;NCGC00141302-01;SMR000142027

Chemical Property of 1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 263.142247555
• Heavy Atom Count: 20
• Complexity: 303

Purity/Quality:

99% ^*data from raw suppliers

1,3-BIS(4-METHYLPHENYL)-1H-PYRAZOL-5-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NN(C(=C2)N)C3=CC=C(C=C3)C

Technology Process of 1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine

There total 1 articles about 1,3-bis(4-methylphenyl)-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-4-methylphenylhydrazine (539-44-6) + p-tolueneacetonitrile (7391-28-8) → 5-amino-1,3-di(p-tolyl)-1H-pyrazole (618092-82-3)

Guidance literature:

montmorillonite MK-10; In isopropyl alcohol; Heating;

Reference yield: 96.0%

5-amino-1,3-di(p-tolyl)-1H-pyrazole (618092-82-3) → (Z)-3-(p-tolyl)-3-((E)-p-tolyldiazenyl)acrylonitrile

Guidance literature:

With [bis(acetoxy)iodo]benzene; In 1,4-dioxane; at 25 ℃; for 0.5h; regioselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2021.153252

Reference yield: 78.0%

5-amino-1,3-di(p-tolyl)-1H-pyrazole (618092-82-3) + 3-Formylchromone (17422-74-1) → 3-[(2,5-di-p-tolyl-2H-pyrazol-3-ylimino)-methyl]-chromen-4-one

Guidance literature:

montmorillonite MK-10; In benzene; Heating;

upstream raw materials:

N-4-methylphenylhydrazine

p-tolueneacetonitrile