(R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: (R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine
• CAS No.: 881207-17-6
• Molecular Formula: C₂₄H₂₅N₇
• Molecular Weight: 411.509

Synonyms:(R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine

Chemical Property of (R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine

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Technology Process of (R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine

There total 1 articles about (R)-N₂-(1-amino-3-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N2-(3-azido-1-phenylpropan-2-yl)-N4-methyl-N4-(2-phenylpyrimidin-4-yl)-pyrimidine-2,4-diamine (881207-16-5) → (R)-N2-(1-amino-3-phenylpropan-2-yl)-N4-methyl-N4-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine (881207-17-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 16h; under 760.051 Torr;

Reference yield:

(R)-N2-(1-amino-3-phenylpropan-2-yl)-N4-methyl-N4-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine (881207-17-6) + acetone (67-64-1) → (R)-N2-(3-(isopropylamino)-1-phenylpropan-2-yl)-N4-methyl-N4-(2-phenyl-pyrimidin-4-yl)pyrimidine-2,4-diamine

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 50 ℃; for 2h;

Reference yield:

(R)-N2-(1-amino-3-phenylpropan-2-yl)-N4-methyl-N4-(2-phenylpyrimidin-4-yl)pyrimidine-2,4-diamine (881207-17-6) + 2-(2-bromoethyl)isoindoline-1,3-dione (574-98-1) → (R)-2-(2-(2-(4-(methyl(2-phenylpyrimidin-4-yl)amino)pyrimidin-2-ylamino)-3-phenylpropylamino)ethyl)isoindoline-1,3-dione

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 16h;

upstream raw materials:

(R)-N₂-(3-azido-1-phenylpropan-2-yl)-N₄-methyl-N₄-(2-phenylpyrimidin-4-yl)-pyrimidine-2,4-diamine

Downstream raw materials:

(R)-tert-butyl 2-(2-(4-(methyl(2-phenylpyrimidin-4-yl)amino)pyrimidin-2-ylamino)-3-phenylpropylamino)-2-oxoethylcarbamate

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