2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

Base Information

Chemical Name:2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid
CAS No.:1426049-75-3
Molecular Formula:C₁₉H₂₃BrN₂O₄
Molecular Weight:423.307
Hs Code.:

Synonyms:2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

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Chemical Property of 2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

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Technology Process of 2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

There total 5 articles about 2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1375107-47-3
4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride

: 5467-74-3
4-Bromophenylboronic acid

: 298-12-4
Glyoxilic acid

: 1426049-75-3
2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

Guidance literature:: 4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride; With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 1h;

4-Bromophenylboronic acid; Glyoxilic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1375107-45-1
1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate

: 1426049-75-3
2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran; water

2.1: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

3.1: sodium hydroxide / dichloromethane; water / 1 h / 20 °C

3.2: 20 °C

With hydrogenchloride; ethanol; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1375107-46-2
1,1-dimethylethyl 4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1426049-75-3
2-(4-bromophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

2.1: sodium hydroxide / dichloromethane; water / 1 h / 20 °C

2.2: 20 °C

With hydrogenchloride; ethanol; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;