(-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride

Base Information

• Chemical Name: (-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride
• CAS No.: 91791-25-2
• Molecular Formula: C₁₆H₁₇NO₂*ClH
• Molecular Weight: 291.777
• Mol file: 91791-25-2.mol

Synonyms:(-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride

Chemical Property of (-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride

There total 1 articles about (-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-2-Amino-1,2-diphenylethanol (23190-16-1) + acetic anhydride (108-24-7) → (-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride (91791-25-2)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1) Acetic acid, 80 degC, 9 h, 2) acetic acid, r.t., 5 h;

DOI:10.1246/bcsj.57.1040

Reference yield: 37.3%

(-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride (91791-25-2) → (SR)-2-acetoxy-2-phenylacetophenone (84275-45-6)

Guidance literature:

With calcium sulfate; potassium permanganate; In water; tert-butyl alcohol; at 60 ℃; for 2h;

DOI:10.1246/bcsj.57.1040

Reference yield:

(-)-erythro-2-amino-1,2-diphenylethyl acetate hydrochloride (91791-25-2) → (R)-benzoin (5928-66-5,579-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 37.3 percent / KMnO₄, CaSO₄*2H₂O / H₂O; 2-methyl-propan-2-ol / 2 h / 60 °C

2: 75 percent / conc. H₂SO₄ / methanol / 2 h / Heating

With calcium sulfate; potassium permanganate; sulfuric acid; In methanol; water; tert-butyl alcohol;

DOI:10.1246/bcsj.57.1040

upstream raw materials:

(1R,2S)-2-Amino-1,2-diphenylethanol

acetic anhydride

Downstream raw materials:

(SR)-2-acetoxy-2-phenylacetophenone

(R)-benzoin