Technology Process of ethyl (R)-6-ethyl-2-oxo-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate
There total 3 articles about ethyl (R)-6-ethyl-2-oxo-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; C21H22N3O(1+)*Cl(1-);
In
toluene;
at 40 ℃;
for 22h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1039/c1cc12778k
- Guidance literature:
-
With
1,4-diaza-bicyclo[2.2.2]octane; (5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; lithium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 14h;
Molecular sieve;
- Guidance literature:
-
With
(5aR,10bS)-2-mesityl-5a,10b-dihydro-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; caesium carbonate; lithium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 36h;
Overall yield = 88 %; Overall yield = 24.1 mg; enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1002/anie.201302152
