4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

Base Information

Chemical Name:4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine
CAS No.:1427588-46-2
Molecular Formula:C₂₂H₂₇N₅O₂
Molecular Weight:393.489
Hs Code.:

Synonyms:4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

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Chemical Property of 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

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Technology Process of 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

There total 8 articles about 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1427588-89-3
{4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methyl methanesulfonate

: 1427588-46-2
4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

Guidance literature:: With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 90 ℃; for 20h;

Reference yield:

: 1427555-72-3
{4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl acetate

: 1427588-46-2
4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium nitrite; acetic acid / water / 0.08 h

2: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation

3: potassium carbonate; methanol / 0.5 h

4: triethylamine / dichloromethane / 1 h

5: potassium carbonate; caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 h / 90 °C

With methanol; potassium phosphate; copper(l) iodide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; N,N`-dimethylethylenediamine; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1427588-82-6
tert-butyl 2-[(acetyloxy)methyl]morpholine-4-carboxylate

: 1427588-46-2
4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-2-(morpholin-4-ylmethyl)morpholine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane

2.1: triethylamine / methanol; 1,2-dichloro-ethane / 0.5 h / 0 °C

2.2: 78 h / 60 °C

3.1: sodium nitrite; acetic acid / water / 0.08 h

4.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation

5.1: potassium carbonate; methanol / 0.5 h

6.1: triethylamine / dichloromethane / 1 h

7.1: potassium carbonate; caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 h / 90 °C

With methanol; potassium phosphate; copper(l) iodide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; N,N`-dimethylethylenediamine; sodium nitrite; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;