3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

Base Information

Chemical Name:3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid
CAS No.:940304-54-1
Molecular Formula:C₂₁H₁₇ClN₄O₄
Molecular Weight:424.843
Hs Code.:

Synonyms:3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

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Chemical Property of 3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

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Technology Process of 3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

There total 3 articles about 3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₃ClN₄O₅

: 940304-54-1
3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

Guidance literature:: C₂₉H₂₃ClN₄O₅; With sodium hydroxide; water; In methanol; at 20 ℃; for 72h;

With hydrogenchloride; In methanol;

Reference yield:

: 884171-79-3
methyl 3-(2-chloro-4-nitrophenoxy)benzoate

: 940304-54-1
3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: platinum on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

2: isopropyl alcohol / 12 h / 80 °C

3: methanol; sodium hydroxide / tetrahydrofuran / 72 h / 20 °C

With methanol; platinum on carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm300185p

Reference yield:

: 350-30-1
3-chloro-4-fluoronitrobenzene

: 940304-54-1
3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: platinum on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

3: isopropyl alcohol / 12 h / 80 °C

4: methanol; sodium hydroxide / tetrahydrofuran / 72 h / 20 °C

With methanol; platinum on carbon; hydrogen; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300185p