N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

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Chemical Name:N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide
CAS No.:940304-53-0
Molecular Formula:C₂₅H₂₆ClN₅O₃
Molecular Weight:479.966
Hs Code.:

Synonyms:N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

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Chemical Property of N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

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Technology Process of N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

There total 4 articles about N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 940304-54-1
3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]-pyrimidin-4-yl]amino}phenoxy)benzoic acid

: 75-64-9
tert-butylamine

: 940304-53-0
N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm300185p

Reference yield:

: 884171-79-3
methyl 3-(2-chloro-4-nitrophenoxy)benzoate

: 940304-53-0
N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: platinum on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

2: isopropyl alcohol / 12 h / 80 °C

3: methanol; sodium hydroxide / tetrahydrofuran / 72 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With methanol; platinum on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300185p

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 940304-53-0
N-tert-butyl-3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo-[3,2-d]pyrimidin-4-yl]amino}phenoxy)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: platinum on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

3: isopropyl alcohol / 12 h / 80 °C

4: methanol; sodium hydroxide / tetrahydrofuran / 72 h / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With methanol; platinum on carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300185p