(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Base Information

Chemical Name:(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol
CAS No.:1310694-25-7
Molecular Formula:C₂₅H₄₀O₂Si
Molecular Weight:400.677
Hs Code.:

Synonyms:(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Suppliers and Price of (R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

There total 5 articles about (R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1310694-19-9
(R,E)-2,8-dimethyl-11-phenylundec-8-en-3-yne-2,5-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1310694-25-7
(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 23 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja204142n

Reference yield:

: 37715-31-4
(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl acetate

: 1310694-25-7
(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: dilithium tetrachlorocuprate / tetrahydrofuran / 2.17 h / 0 °C / Inert atmosphere

2: sodium periodate; periodic acid dihydrate / tetrahydrofuran; water / 0 - 23 °C / Inert atmosphere

3: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 23 °C / Inert atmosphere

4: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 23 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; periodic acid dihydrate; dilithium tetrachlorocuprate; (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja204142n

Reference yield:

: 1029390-49-5
2,2-dimethyl-3-(3-methyl-6-phenylhex-3-en-1-yl)oxirane

: 1310694-25-7
(R,E)-5-(tert-butyldimethylsilyloxy)-2,8-dimethyl-11-phenylundec-8-en-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate; periodic acid dihydrate / tetrahydrofuran; water / 0 - 23 °C / Inert atmosphere

2: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 23 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 23 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; periodic acid dihydrate; (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja204142n