([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

Base Information

Chemical Name:([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)
CAS No.:1401937-65-2
Molecular Formula:C₂₈H₃₃NO₄
Molecular Weight:447.574
Hs Code.:

Synonyms:([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

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Chemical Property of ([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

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Technology Process of ([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

There total 6 articles about ([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1401938-11-1
[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

: 1401937-65-2
([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 4h;

Reference yield:

: C₂₇H₂₉NO₅

: 1401937-65-2
([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jm401639v

Reference yield:

: 1318265-17-6
3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethyl)estra-1,3,5(10)-trien-16-yl]methyl}benzamide

: 1401937-65-2
([(16β,17β)-16-(3-carbamoylbenzyl)-17-hydroxyestra-1(10),2,4-trien-3-yl]acetic acid)

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: sodium tetrahydroborate; methanol / 4 h / 20 °C

With methanol; sodium tetrahydroborate; Dess-Martin periodane; In dichloromethane;