[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

Base Information

Chemical Name:[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid
CAS No.:1401938-11-1
Molecular Formula:C₂₈H₃₁NO₄
Molecular Weight:445.558
Hs Code.:

Synonyms:[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

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Chemical Property of [(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

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Technology Process of [(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

There total 4 articles about [(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318265-17-6
3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethyl)estra-1,3,5(10)-trien-16-yl]methyl}benzamide

: 1401938-11-1
[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

Guidance literature:: 3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethyl)estra-1,3,5(10)-trien-16-yl]methyl}benzamide; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 12h;

Reference yield:

: 1318265-24-5
3-{(E)-[(16E)-3-[2-(benzyloxy)ethyl]-17-oxoestra-1⁽¹⁰⁾,2,4-trien-16-ylidene]methyl}benzamide

: 1401938-11-1
[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h / 20 °C

1.2: 36 h

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2.2: 12 h / 20 °C

With methanol; sodium tetrahydroborate; Dess-Martin periodane; In dichloromethane;

Reference yield:

: 1318265-21-2
(8R,9S,13S,14S)-13-methyl-3-vinyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolane]

: 1401938-11-1
[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 20 °C

2.3: 5 h / 20 °C

3.1: potassium hydroxide; water / ethanol / 0.5 h / Reflux

4.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h / 20 °C

4.2: 36 h

5.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.2: 12 h / 20 °C

With methanol; sodium tetrahydroborate; dimethylsulfide borane complex; water; sodium hydride; Dess-Martin periodane; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;