2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

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Chemical Name:2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide
CAS No.:1383922-54-0
Molecular Formula:C₂₃H₁₉ClN₄O₃
Molecular Weight:434.882
Hs Code.:

Synonyms:2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

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Chemical Property of 2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

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Technology Process of 2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

There total 7 articles about 2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 20265-39-8
4-amino-2-methoxypyridine

: 1383924-42-2
2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxoacetic acid

: 1383922-54-0
2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; acetonitrile; at 60 ℃; for 14h;

Reference yield:

: 6298-19-7
2-chloro-3-aminopyridine

: 1383922-54-0
2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 14 h / 10 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 13.5 h / Reflux; Heating

3.1: sodium hydroxide; ethanol / 1.5 h / 80 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 12 h / 20 °C

5.1: aluminum (III) chloride / dichloromethane / 3.33 h / 20 °C

5.2: Cooling with ice

6.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; acetonitrile / 14 h / 60 °C

With aluminum (III) chloride; ethanol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium chloride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; 5.1: Friedel Crafts Acylation;

Reference yield:

: 545384-32-5
ethyl (2-chloropyridin-3-yl)carbamate

: 1383922-54-0
2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 13.5 h / Reflux; Heating

2.1: sodium hydroxide; ethanol / 1.5 h / 80 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 12 h / 20 °C

4.1: aluminum (III) chloride / dichloromethane / 3.33 h / 20 °C

4.2: Cooling with ice

5.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; acetonitrile / 14 h / 60 °C

With aluminum (III) chloride; ethanol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium chloride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile; 4.1: Friedel Crafts Acylation;