methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

Base Information

Chemical Name:methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate
CAS No.:1331836-44-2
Molecular Formula:C₁₈H₁₉NO₅S
Molecular Weight:361.419
Hs Code.:

Synonyms:methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

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Chemical Property of methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

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Technology Process of methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

There total 2 articles about methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1117-71-1
methyl 4-bromocrotonate

: 1331836-53-3
C₁₃H₁₁NO₃S

: 1331836-44-2
methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

Guidance literature:: With diethylaluminium chloride; copper(I) bromide; zinc; In tetrahydrofuran; at -20 ℃; for 15.66h; Inert atmosphere;
DOI:10.1021/ol201510u

Reference yield:

: 1229516-61-3
3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carbaldehyde

: 1331836-44-2
methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 24 h / Reflux

2: diethylaluminium chloride; copper(I) bromide; zinc / tetrahydrofuran / 15.66 h / -20 °C / Inert atmosphere

With palladium diacetate; diethylaluminium chloride; caesium carbonate; triphenylphosphine; copper(I) bromide; zinc; In tetrahydrofuran; water; 1: Suzuki-Miyaura coupling;
DOI:10.1021/ol201510u

Reference yield:

: 1331836-44-2
methyl 2-(hydroxy(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)methyl)but-3-enoate

: C₁₆H₁₅NO₅S

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol201510u