2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol

Base Information

Chemical Name:2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol
CAS No.:117347-91-8
Molecular Formula:C₁₇H₁₈N₄OS
Molecular Weight:326.422
Hs Code.:
DSSTox Substance ID:DTXSID701146335

Synonyms:SCHEMBL9666041;DTXSID701146335;2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol;117347-91-8

Suppliers and Price of 2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:326.12013238
Heavy Atom Count:23
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C1=CC=CC=C1CSC2=NC=CN2C3=C(C=CC=N3)O

Technology Process of 2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol

There total 6 articles about 2-[2-[[[2-(Dimethylamino)phenyl]methyl]thio]-1H-imidazol-1-yl]-3-pyridinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106771-59-9
2-(chloromethyl)-N,N-dimethylaniline

: 117296-81-8
1-(3-Hydroxy-pyridin-2-yl)-1,3-dihydro-imidazole-2-thione

: 117347-91-8
1-(3-hydroxy-pyridin-2-yl)-2-(2-dimethylaminobenzylthio)imidazole

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1021/jm950610n

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 117347-91-8
1-(3-hydroxy-pyridin-2-yl)-2-(2-dimethylaminobenzylthio)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 18 h / Heating

2: AcOH, HCl / 18 h / Heating

3: NaOH / dimethylformamide / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; acetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm950610n

Reference yield:

: 394-35-4
methyl 2-fluorobenzoate

: 117347-91-8
1-(3-hydroxy-pyridin-2-yl)-2-(2-dimethylaminobenzylthio)imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran

3: SOCl₂ / CHCl₃

4: NaOH / dimethylformamide / 3 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm950610n