1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

Base Information

Chemical Name:1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt
CAS No.:1403232-17-6
Molecular Formula:C₄H₁₁N*C₂₆H₃₀ClN₃O₃
Molecular Weight:541.134
Hs Code.:

Synonyms:1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

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Chemical Property of 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

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Technology Process of 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

There total 10 articles about 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403232-16-5
1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

: 75-64-9
tert-butylamine

: 1403232-17-6
1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

Guidance literature:: In methanol; dichloromethane;

Reference yield:

: 1403233-54-4
4-isobutyl-3-nitrobenzaldehyde

: 1403232-17-6
1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; tin(ll) chloride / water / 0.5 h / 0 - 65 °C

1.2: 0.17 h / 0 - 20 °C

1.3: 0.33 h / 60 - 65 °C

2.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 4 h / 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 120 - 125 °C

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 45 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C

6.1: sodium hydroxide; potassium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 80 °C

6.2: pH ~ 4 - 5

With hydrogenchloride; sodium chlorite; thionyl chloride; sodium dihydrogenphosphate dihydrate; water; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; tin(ll) chloride; potassium hydroxide; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1403234-01-4
{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]-phenyl} methanol

: 1403232-17-6
1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid tert-butyl amine salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 45 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C

3.1: sodium hydroxide; potassium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 80 °C

3.2: pH ~ 4 - 5

With thionyl chloride; water; potassium carbonate; potassium hydroxide; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;