ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

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Chemical Name:ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate
CAS No.:1041260-88-1
Molecular Formula:C₁₇H₂₀N₄O₃
Molecular Weight:328.371
Hs Code.:

Synonyms:ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

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Chemical Property of ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

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Technology Process of ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

There total 7 articles about ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1041015-44-4
5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

: 1041260-88-1
ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; water; at 20 ℃; for 12h;
DOI:10.1021/jm300204j

Reference yield:

: 718632-46-3
5-(tert-butyl) 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

: 1041260-88-1
ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; ethanol; water / 12 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/jm300204j

Reference yield:

: 718632-38-3
2-[(tert-butoxycarbonyl)(2-cyanoethyl)amino]-2-methylpropanoic acid

: 1041260-88-1
ethyl 3-benzamido-6,6-dimethyl-5,6-dihydropyrrolo[3,4-c]-pyrazole-2(4H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 20 - 40 °C

2: potassium tert-butylate / toluene / 0 - 5 °C

3: hydrazine hydrate; acetic acid / ethanol / 12 h / Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

6: hydrogenchloride / 1,4-dioxane; ethanol; water / 12 h / 20 °C

With hydrogenchloride; potassium tert-butylate; potassium hydrogencarbonate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300204j