5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Base Information

Chemical Name:5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate
CAS No.:1041015-44-4
Molecular Formula:C₂₂H₂₈N₄O₅
Molecular Weight:428.488
Hs Code.:

Synonyms:5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

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Chemical Property of 5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

There total 5 articles about 5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718632-38-3
2-[(tert-butoxycarbonyl)(2-cyanoethyl)amino]-2-methylpropanoic acid

: 1041015-44-4
5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 20 - 40 °C

2: potassium tert-butylate / toluene / 0 - 5 °C

3: hydrazine hydrate; acetic acid / ethanol / 12 h / Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With potassium tert-butylate; potassium hydrogencarbonate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300204j

Reference yield:

: 718632-40-7
methyl 2-[(tert-butoxycarbonyl)(2-cyanoethyl)amino]-2-methylpropanoate

: 1041015-44-4
5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / toluene / 0 - 5 °C

2: hydrazine hydrate; acetic acid / ethanol / 12 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With potassium tert-butylate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm300204j

Reference yield:

: 946497-94-5
tert-butyl 4-cyano-3-hydroxy-2,2-dimethyl-2,5-dihydro-1Hpyrrole-1-carboxylate

: 1041015-44-4
5-(tert-butyl) 2-ethyl 3-benzamido-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate; acetic acid / ethanol / 12 h / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm300204j