tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate

Base Information

• Chemical Name: tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate
• CAS No.: 1259367-14-0
• Molecular Formula: C₂₁H₃₂ClFN₆O₄
• Molecular Weight: 486.974

Synonyms:tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate

Chemical Property of tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate

Chemical Property:

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Technology Process of tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate

There total 1 articles about tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-(N-tert-butoxycarbonyl-C-pyrazol-1-yl-carbonimidoyl)carbamate + (1S,3R)-N1-(2-chloro-5-fluoro-pyrimidin-4-yl)cyclohexane-1,3-diamine (1259367-15-1) → tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate (1259367-14-0)

Guidance literature:

In dichloromethane;

Reference yield:

palladium-triphenylphosphine (12628-74-9) + (Z)-tert-butyl (tert-butoxycarbonylamino) ((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino) methylenecarbamate + 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1259279-57-6) + tert-butyl (tert-butoxycarbonylamino)((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexylamino)methylenecarbamate (1259367-14-0) → tert-butyl N-[N-[(1R,3S)-3-[[5-fluoro-2-[5-fluoro-1-(p-tolylsulfonyl)-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]amino]cyclohexyl]carbamimidoyl]-carbamate (1259367-16-2)

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane;

upstream raw materials:

(1S,3R)-N₁-(2-chloro-5-fluoro-pyrimidin-4-yl)cyclohexane-1,3-diamine

Downstream raw materials:

tert-butyl N-[N-[(1R,3S)-3-[[5-fluoro-2-[5-fluoro-1-(p-tolylsulfonyl)-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]amino]cyclohexyl]carbamimidoyl]-carbamate

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