2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

Base Information

Chemical Name:2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine
CAS No.:1353968-55-4
Molecular Formula:C₂₃H₁₂Cl₂FN₃
Molecular Weight:420.273
Hs Code.:

Synonyms:2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

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Chemical Property of 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

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Technology Process of 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

There total 7 articles about 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323919-45-4
2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridine-4-boronic acid

: 956003-79-5
8-chloro-5-bromo-isoquinoline

: 1353968-55-4
2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: With potassium phosphate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃;

Reference yield:

: 5345-47-1
2-aminopyridin-3-carboxylic acid

: 1353968-55-4
2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 60 h / 79 °C / Industry scale

1.2: pH 7 / Cooling with ice; Industry scale

2.1: sodium ethanolate / ethanol / 1 h / 20 °C / Industry scale

2.2: 65 h / 85 °C / Industry scale

3.1: hydrogenchloride / water / 17.5 h / 72 °C / Industry scale; Reflux

3.2: 16 h / 5 - 8 °C / pH 5 / Industry scale

4.1: trichlorophosphate / toluene / 4 h / 100 °C

4.2: 20 °C

5.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

6.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

7.1: potassium phosphate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

With hydrogenchloride; potassium phosphate; sulfuric acid; sodium ethanolate; potassium acetate; sodium hydrogencarbonate; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13362-26-0
2-aminopyridine-3-carboxylic acid ethyl ester

: 1353968-55-4
2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 1 h / 20 °C / Industry scale

1.2: 65 h / 85 °C / Industry scale

2.1: hydrogenchloride / water / 17.5 h / 72 °C / Industry scale; Reflux

2.2: 16 h / 5 - 8 °C / pH 5 / Industry scale

3.1: trichlorophosphate / toluene / 4 h / 100 °C

3.2: 20 °C

4.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

5.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

6.1: potassium phosphate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 80 °C

With hydrogenchloride; potassium phosphate; sodium ethanolate; potassium acetate; sodium hydrogencarbonate; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene;