2,4-Dichloro-1,8-naphthyridine

Base Information

• Chemical Name: 2,4-Dichloro-1,8-naphthyridine
• CAS No.: 59514-89-5
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.039
• Hs Code.: 2933990090
• European Community (EC) Number: 811-054-7
• DSSTox Substance ID: DTXSID40593906
• Wikidata: Q72467030
• Mol file: 59514-89-5.mol

Synonyms:2,4-DICHLORO-1,8-NAPHTHYRIDINE;59514-89-5;MFCD00234380;1,8-Naphthyridine, 2,4-dichloro-;SCHEMBL247512;DTXSID40593906;CCQHBZIXZFQYSO-UHFFFAOYSA-N;2,4-dichloro-[1,8]naphthyridine;AMY28787;CS-D0002;2,4-Dichloro-1,8-diazanaphthalene;2,4-Dichloro-pyrido[2,3-b]pyridine;AKOS006275506;DS-15551;SY056513;DB-072654;D4896;EN300-301931;2 pound not4-Dichloro-1 pound not8-naphthyridine;J-507111

Chemical Property of 2,4-Dichloro-1,8-naphthyridine

Chemical Property:

• Vapor Pressure: 0.00216mmHg at 25°C
• Melting Point: 123.0 to 127.0 °C
• Refractive Index: 1.67
• Boiling Point: 299.1 °C at 760 mmHg
• PKA: 1.15±0.30(Predicted)
• Flash Point: 163 °C
• PSA: 25.78000
• Density: 1.486 g/cm³
• LogP: 2.93660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 197.9751535
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-1,8-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)N=C(C=C2Cl)Cl

Technology Process of 2,4-Dichloro-1,8-naphthyridine

There total 8 articles about 2,4-Dichloro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

[1,8]naphthyridine-2,4-diol (59514-86-2) → 2,4-dichloro-[1,8]naphthyridine (59514-89-5)

Guidance literature:

With trichlorophosphate; at 90 ℃;

Reference yield: 49.0%

2-aminopyridine (504-29-0) + malonoyl dichloride (1663-67-8) → 2,4-dichloro-[1,8]naphthyridine (59514-89-5)

Guidance literature:

at 0 ℃; for 4h; Reflux;

DOI:10.1021/jm5005978

Reference yield: 47.0%

1-benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one (219775-95-8) → 2,4-dichloro-[1,8]naphthyridine (59514-89-5) + 1-benzyl-4-chloro-1,8-naphthyridin-2(1H)-one (583031-57-6)

Guidance literature:

With trichlorophosphate; for 2h; Heating / reflux;

upstream raw materials:

1-benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one

2-aminopyridin-3-carboxylic acid

[1,8]naphthyridine-2,4-diol

2-aminopyridine-3-carboxylic acid ethyl ester

Downstream raw materials:

4-chloro-1,8-naphthyridin-2-one

4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-hydroxy-ethyl)-2H-[2,7]naphthyridin-1-one

4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethyl)-2H-[2,7]naphthyridin-1-one

2-(5-chloro-2-fluoro-phenyl)-4-[1-(2-morpholin-4-yl-ethoxy)-[2,7]naphthyridin-4-yl]-[1,8]naphthyridine