2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Base Information

Chemical Name:2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide
CAS No.:1469996-70-0
Molecular Formula:C₃₀H₃₀ClF₃N₂O₃
Molecular Weight:559.028
Hs Code.:

Synonyms:2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

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Chemical Property of 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

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Technology Process of 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

There total 4 articles about 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1469996-65-3
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

: 98-16-8
3-trifluoromethylaniline

: 1469996-70-0
2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 5 - 20 ℃; for 16.5h;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 17193-39-4,144644-00-8
methyl 3-cyclohexyl-L-alaninate hydrochloride

: 1469996-70-0
2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

2: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 1469996-58-4
methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate

: 1469996-70-0
2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009