(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

Base Information

Chemical Name:(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid
CAS No.:1469996-65-3
Molecular Formula:C₂₃H₂₆ClNO₄
Molecular Weight:415.917
Hs Code.:

Synonyms:(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

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Chemical Property of (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

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Technology Process of (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

There total 3 articles about (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1469996-58-4
methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate

: 1469996-65-3
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 50 ℃; for 0.75h;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 17193-39-4,144644-00-8
methyl 3-cyclohexyl-L-alaninate hydrochloride

: 1469996-65-3
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

2: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

: 25528-71-6
(S)-2-amino-3-cyclohexylpropionic acid hydrochloride

: 1469996-65-3
(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 16 h / -10 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

3: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

With thionyl chloride; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.08.009