(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

Base Information

Chemical Name:(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester
CAS No.:1079398-47-2
Molecular Formula:C₃₃H₅₀N₄O₇
Molecular Weight:614.783
Hs Code.:

(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

Synonyms:(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

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Chemical Property of (1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

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Technology Process of (1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

There total 13 articles about (1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1079398-46-1
(1R/S-{3-[2S-azido-2S-(4R-methoxy-5-oxotetrahvdrofuran-2S-yl)ethoxymethyl]-phenyl} - ethyl)-carbamic acid-tert-butylester

: 106566-02-3,120369-25-7,144902-31-8
L-valine benzylamide

: 1079398-47-2
(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

Guidance literature:: (1R/S-{3-[2S-azido-2S-(4R-methoxy-5-oxotetrahvdrofuran-2S-yl)ethoxymethyl]-phenyl} - ethyl)-carbamic acid-tert-butylester; L-valine benzylamide; With 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 70 ℃;

With triphenylphosphine; In methanol; water; at 20 ℃;

Reference yield:

: 1079398-63-2
methyl 5,6-di-O-benzyl-3-deoxy-D-glucofuranoside

: 1079398-47-2
(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 10.5 h / 0 - 20 °C

2.1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

3.1: dipyridinium dichromate / dichloromethane / 12 h / 0 - 20 °C / Molecular sieve

4.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

5.1: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

6.1: pyridine / dichloromethane / 0.5 h / 0 °C

7.1: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

8.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

8.2: 20 °C

With pyridine; 2-hydroxypyridin; dipyridinium dichromate; sodium azide; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; sodium hydride; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1079398-42-7
C₂₂H₂₈O₅

: 1079398-47-2
(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

2.1: dipyridinium dichromate / dichloromethane / 12 h / 0 - 20 °C / Molecular sieve

3.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

4.1: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

5.1: pyridine / dichloromethane / 0.5 h / 0 °C

6.1: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

7.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

7.2: 20 °C

With pyridine; 2-hydroxypyridin; dipyridinium dichromate; sodium azide; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;