N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

Base Information

Chemical Name:N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester
CAS No.:1079398-50-7
Molecular Formula:C₄₇H₆₇N₅O₁₂S
Molecular Weight:926.141
Hs Code.:

N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

Synonyms:N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

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Chemical Property of N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

There total 20 articles about N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1079398-49-4
5-(methanesulphonyl-methyl-amino)-isophthalic acid mono-tert-butyl ester

: 1079398-47-2
(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-3S-hydroxy-5R-methoxypentyloxymethyl]-phenyl}-ethyl) carbamic acid tert-butyl ester

: 1079398-50-7
N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.41667h;

Reference yield:

: 1079398-63-2
methyl 5,6-di-O-benzyl-3-deoxy-D-glucofuranoside

: 1079398-50-7
N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 10.5 h / 0 - 20 °C

2.1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

3.1: dipyridinium dichromate / dichloromethane / 12 h / 0 - 20 °C / Molecular sieve

4.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

5.1: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

6.1: pyridine / dichloromethane / 0.5 h / 0 °C

7.1: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

8.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

8.2: 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.42 h / 0 - 20 °C

With pyridine; 2-hydroxypyridin; dipyridinium dichromate; sodium azide; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; sodium hydride; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; HATU; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1079398-43-8
C₂₁H₂₄O₅

: 1079398-50-7
N-{4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-1S-[3-(1R/S-tert-butoxycarbonyl-aminoethyl)-benzyloxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonylmethylamino)isophthalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

2.1: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

3.1: pyridine / dichloromethane / 0.5 h / 0 °C

4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

5.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

5.2: 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.42 h / 0 - 20 °C

With pyridine; 2-hydroxypyridin; sodium azide; tetrabutylammomium bromide; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; HATU; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;