3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate

Base Information

• Chemical Name: 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate
• CAS No.: 100410-78-4
• Molecular Formula: C₂₃H₁₈O₅
• Molecular Weight: 374.393
• Mol file: 100410-78-4.mol

Synonyms:3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate

Chemical Property of 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate

There total 3 articles about 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1) + benzoyl chloride (98-88-4) → 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate (100410-78-4)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Reflux;

DOI:10.1016/j.bmcl.2013.02.095

Reference yield:

2-methylbenzene-1,3-diol (608-25-3) → 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate (100410-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / 70 °C

1.2: 7 h / 20 - 80 °C

2.1: potassium carbonate / acetone / 8 h / Reflux

With boron trifluoride diethyl etherate; potassium carbonate; In acetone; 1.1: |Friedel-Crafts Acylation / 2.1: |Baker-Venkataraman Rearrangement;

DOI:10.1016/j.bmcl.2013.02.095

Reference yield:

→ 3-hydroxy-2-methyl-4-(3-oxo-3-phenylpropanoyl)phenyl benzoate (100410-78-4)

Guidance literature:

Aceton XIXb;

upstream raw materials:

2-methylbenzene-1,3-diol

1-(2,4-dihydroxy-3-methylphenyl)ethanone

benzoyl chloride

Downstream raw materials:

7-hydroxy-8-methyl-2-phenyl-4H-benzofuro<3,2-g><1>benzopyran-4-one

7-(2-bromoethoxy)-8-methyl-2-phenyl-4H-chromen-4-one

7-(3-bromopropoxy)-8-methyl-2-phenyl-4H-chromen-4-one

7-(4-bromobutoxy)-8-methyl-2-phenyl-4H-chromen-4-one