(3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

Base Information

Chemical Name:(3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole
CAS No.:1253965-66-0
Molecular Formula:C₂₃H₂₈N₂
Molecular Weight:332.489
Hs Code.:

Synonyms:(3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

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Chemical Property of (3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

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Technology Process of (3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

There total 1 articles about (3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (1R,2R,1'S,1''S)-N,N'-di(α-phenylethyl)-4-cyclohexene-1,2-diamine

: 1253965-66-0
(3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

Guidance literature:: formaldehyd; (1R,2R,1'S,1''S)-N,N'-di(α-phenylethyl)-4-cyclohexene-1,2-diamine; With magnesium sulfate; toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; Inert atmosphere;
DOI:10.1021/ol102103y

Reference yield: 20.0%

: 1253965-66-0
(3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole

: 1253965-68-2
C₂₃H₃₀N₂

: C₂₃H₃₂N₂O

: C₂₃H₃₂N₂O

: 1253965-67-1
C₂₃H₃₀N₂O

: C₂₃H₃₀N₂O

Guidance literature:: (3aR,7aR)-1,3-bis[(1S)-1-phenylethyl]-2,3,3a,4,7,7a-hexahydro-1H-benzimidazole; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol102103y