C₂₇H₂₇NO₃S

Base Information

Chemical Name:C₂₇H₂₇NO₃S
CAS No.:1446653-64-0
Molecular Formula:C₂₇H₂₇NO₃S
Molecular Weight:445.582
Hs Code.:

C<sub>27</sub>H<sub>27</sub>NO<sub>3</sub>S

Synonyms:C₂₇H₂₇NO₃S

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Chemical Property of C₂₇H₂₇NO₃S

Chemical Property:

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Technology Process of C₂₇H₂₇NO₃S

There total 12 articles about C₂₇H₂₇NO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1446655-38-4
C₂₈H₂₉NO₃S

: 1446653-64-0
C₂₇H₂₇NO₃S

Guidance literature:: C₂₈H₂₉NO₃S; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1446653-64-0
C₂₇H₂₇NO₃S

Guidance literature:: Multi-step reaction with 12 steps

1.1: thionyl chloride / Reflux

2.1: potassium carbonate / water; diethyl ether / 2 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 20 - 40 °C

4.1: cesium fluoride / N,N-dimethyl-formamide / 40 h / 60 °C

5.1: 1 h / 0 - 20 °C

5.2: 48 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 - 20 °C

6.2: pH 3 - 4

7.1: borane-THF / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

9.1: potassium hydrogencarbonate / 0.5 h / 0 °C

10.1: triethylamine / dichloromethane / 0.5 h / 0 °C

11.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C

12.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

12.2: pH 4 - 5

With thionyl chloride; borane-THF; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; caesium carbonate; triethylamine; cesium fluoride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 33996-30-4
trans-4-hydroxy-L-proline ethyl ester hydrochloride

: 1446653-64-0
C₂₇H₂₇NO₃S

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / water; diethyl ether / 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 20 - 40 °C

3.1: cesium fluoride / N,N-dimethyl-formamide / 40 h / 60 °C

4.1: 1 h / 0 - 20 °C

4.2: 48 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 - 20 °C

5.2: pH 3 - 4

6.1: borane-THF / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

8.1: potassium hydrogencarbonate / 0.5 h / 0 °C

9.1: triethylamine / dichloromethane / 0.5 h / 0 °C

10.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C

11.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

11.2: pH 4 - 5

With borane-THF; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; caesium carbonate; triethylamine; cesium fluoride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;