(1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester
• CAS No.: 622367-01-5
• Molecular Formula: C₃₂H₄₈N₆O₇
• Molecular Weight: 628.769
• Mol file: 622367-01-5.mol

Synonyms:(1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester

Chemical Property of (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester

There total 6 articles about (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-amino-3-methylbutane (107-85-7) + [N4-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid (144564-95-4) + isovaleraldehyde (590-86-3) + (N-tert-butyloxycarbonyl)aminoethyl isocyanide (215254-91-4) → (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester (622367-01-5)

Guidance literature:

In isopropyl alcohol; at 20 ℃; for 48h;

DOI:10.1055/s-2003-39391

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester (622367-01-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 75 percent / tetrahydrofuran / 24.5 h / 0 - 20 °C

2.1: 90 percent / DCC / CH₂Cl₂ / 20 °C

3.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h / ice bath

3.2: 68 percent / aq. K₂CO₃ / CH₂Cl₂ / 0.5 h

4.1: 62 percent / propan-2-ol / 48 h / 20 °C

With triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 4.1: Ugi four-component reaction;

DOI:10.1055/s-2003-39391

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester (622367-01-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 33 percent / pyridine / 20 h / 0 °C

2: K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 7.76 g / aq. NaOH / 0.5 h / 20 °C

4: 62 percent / propan-2-ol / 48 h / 20 °C

With pyridine; sodium hydroxide; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol; 4: Ugi four-component reaction;

DOI:10.1055/s-2003-39391

upstream raw materials:

1-amino-3-methylbutane

[N⁴-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

isovaleraldehyde

(N-tert-butyloxycarbonyl)aminoethyl isocyanide