4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

Base Information

Chemical Name:4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine
CAS No.:376608-72-9
Molecular Formula:C₁₄H₁₆N₄O₂S
Molecular Weight:304.373
Hs Code.:

Synonyms:4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

Suppliers and Price of 4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

There total 1 articles about 4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

: 145783-12-6
4,6-dihydroxy-2-(propylsulfanyl)pyrimidine

: 106-49-0,12221-03-3
p-toluidine

: 376608-72-9
4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

Guidance literature:: 4,6-dihydroxy-2-(propylsulfanyl)pyrimidine; With sodium acetate; sodium hydroxide; In ethanol; water; at 20 ℃;

p-toluidine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

In ethanol; water; at 0 - 5 ℃;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 376608-72-9
4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

: 274693-27-5,2096989-55-6,2096989-56-7
ticagrelor

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine; trichlorophosphate / toluene / 4.75 h / 70 °C

2: ammonium formate; zinc / methanol; isopropyl alcohol / 0.33 h

3: hydrogen / 11 h / 20 °C

4: triethylamine; sodium iodide / 1,4-dioxane / 7 h / 120 °C

5: sodium nitrite / water; acetic acid; ethyl acetate / 30 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

7: hydrogenchloride; water / methanol / 1 h

With pyridine; hydrogenchloride; water; hydrogen; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; zinc; sodium nitrite; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 376608-72-9
4,6-dihydroxy-5-((E)-2-(4-methylphenyl)diazenyl)-2-(propylsulfanyl)pyrimidine

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; trichlorophosphate / toluene / 4.75 h / 70 °C

2: ammonium formate; zinc / methanol; isopropyl alcohol / 0.33 h

3: hydrogen / 11 h / 20 °C

With pyridine; hydrogen; ammonium formate; zinc; trichlorophosphate; In methanol; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2012.04.050