4-fluoro-N-(4-methylbenzyl)benzamide

Base Information

• Chemical Name: 4-fluoro-N-(4-methylbenzyl)benzamide
• CAS No.: 346698-40-6
• Molecular Formula: C₁₅H₁₄FNO
• Molecular Weight: 243.281
• Mol file: 346698-40-6.mol

Synonyms:4-fluoro-N-(4-methylbenzyl)benzamide

Chemical Property of 4-fluoro-N-(4-methylbenzyl)benzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-N-(4-methylbenzyl)benzamide

There total 3 articles about 4-fluoro-N-(4-methylbenzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Methylbenzyl alcohol (589-18-4) + 4-fluorobenzonitrile (1194-02-1,143234-87-1) → 4-fluoro-N-(4-methylbenzyl)benzamide (346698-40-6)

Guidance literature:

With SiO₂ coated on magnetic CoFe₂O₄ nanoparticle immobilized N-propyldiethylenetriamine sulfamic acid; at 80 ℃; for 4h; Green chemistry;

DOI:10.1016/j.apcata.2014.06.006

Reference yield: 74.0%

p-fluorobenzamide (824-75-9) + p-tolualdehyde p-toluenesulfonylhydrazone (40739-81-9) → 4-fluoro-N-(4-methylbenzyl)benzamide (346698-40-6)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetra-(n-butyl)ammonium iodide; sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201500331

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 4-fluoro-N-(4-methylbenzyl)benzamide (346698-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 40 °C / Inert atmosphere

2: sodium hydroxide; tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 3 h / 80 °C / Sealed tube; Inert atmosphere

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetra-(n-butyl)ammonium iodide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1002/adsc.201500331

upstream raw materials:

4-Methylbenzyl alcohol

4-fluorobenzonitrile

4-methyl-benzaldehyde

p-fluorobenzamide

Refernces

• 1、 Zhao, Xiao-Na,Hu, Hai-Chuan,Zhang, Fu-Jun,Zhang, Zhan-Hui. "Magnetic CoFe2O4 nanoparticle immobilized N-propyl diethylenetriamine sulfamic acid as an efficient and recyclable catalyst for the synthesis of amides via the Ritter reaction". . p. 258 - 265. Retrieved 2014/07/08.