2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Base Information

• Chemical Name: 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
• CAS No.: 911064-58-9
• Molecular Formula: C7H8 F3 N3 . ClH
• Molecular Weight: 227.617
• Hs Code.: 2933990090
• Mol file: 911064-58-9.mol

Synonyms:Imidazo[1,2-a]pyrazine,5,6,7,8-tetrahydro-2-(trifluoromethyl)-, monohydrochloride (9CI);2-Trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazinehydrochloride salt

Chemical Property of 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Chemical Property:

• Melting Point: ca 220℃
• PSA: 29.85000
• LogP: 2.13590
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic

Purity/Quality:

97% ^*data from raw suppliers

2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-A]pyrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

There total 1 articles about 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine hydrochloride salt (911064-58-9)

Guidance literature:

Reference yield: 73.0%

(4R,5S)-5-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)cyclohex-1-ene-1-carboxylic acid (913623-68-4) + 2-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine hydrochloride salt (911064-58-9) → (1S,6R)-[3-(2-trifluoromethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carbonyl)-6-(2,4,5-trifluoro-phenyl)-cyclohex-3-enyl]-carbamic acid tert-butyl ester (927206-55-1)

Guidance literature:

(4R,5S)-5-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)cyclohex-1-ene-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃;

2-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine hydrochloride salt; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 47.0%

2-chloro-1-(4-chlorophenyl)-9-ethyl-1,9-dihydro-6H-purin-6-one (852854-33-2) + 2-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine hydrochloride salt (911064-58-9) → 1-(4-chlorophenyl)-9-ethyl-2-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-1,9-dihydro-6H-purin-6-one

Guidance literature:

With triethylamine; In tetrahydrofuran; at 150 ℃; for 3h; Smith Synthesizer microwave;

Downstream raw materials:

(1S,6R)-[3-(2-trifluoromethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carbonyl)-6-(2,4,5-trifluoro-phenyl)-cyclohex-3-enyl]-carbamic acid tert-butyl ester

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