913623-68-4

Usage

Chemical structure

A complex structure that includes a cyclohexene ring and a carboxylic acid group.

Functional groups

Contains a trifluorophenyl group and an amino group protected by a dimethylethoxy carbonyl moiety.

Stereochemistry

The compound is chiral with a 4R,5S stereochemistry.

Potential applications

May have potential applications in the pharmaceutical industry, particularly in the development of new drugs or as a building block for the synthesis of other compounds.

Specific properties and uses

These would depend on its individual characteristics and the results of further research and testing.

Upstream product

• 915100-66-2 (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene 
• 913623-66-2 methyl (4R,5S)-5-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)cyclohex-1-ene-1-carboxylate 

Downstream Products

• 927206-55-1 (1S,6R)-[3-(2-trifluoromethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carbonyl)-6-(2,4,5-trifluoro-phenyl)-cyclohex-3-enyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)

The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atheroscler

Discovery of ((4R,5S)-5-amino-4-(2,4,5-trifluorophenyl)cyclohex-1-enyl)-3- (trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor

Dipeptidyl peptidase IV (DPP4) deactivates glucose-regulating hormones such as GLP-1 and GIP, thus, DPP4 inhibition has become a useful therapy for type 2 diabetes. Optimization of the high-throughput screening lead 6 led to the discovery of 25 (ABT-341),