Cyflumetofen

Base Information

• Chemical Name: Cyflumetofen
• CAS No.: 400882-07-7
• Molecular Formula: C₂₄H₂₄F₃NO₄
• Molecular Weight: 447.454
• Mol file: 400882-07-7.mol

Synonyms:2-methoxyethyl (RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionate;

Chemical Property of Cyflumetofen

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 533.764 °C at 760 mmHg
• Flash Point: 276.611 °C
• PSA: 76.39000
• Density: 1.214 g/cm³
• LogP: 4.83678

Purity/Quality:

99.9% ^*data from raw suppliers

Cyflumetofen ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 20-43-50
• Safety Statements: 36/37-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyflumetofen

There total 4 articles about Cyflumetofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

2-methoxyethyl 2-cyano-2-(4-(tert-butyl)phenyl)acetate (400882-57-7) + 2-trifluoromethylbenzoyl chloride (312-94-7) → (RS)-2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate (400882-07-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1016/j.bmc.2020.115509

Reference yield:

4-tert-butylbenzyl cyanide (3288-99-1) → (RS)-2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate (400882-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 20 - 56 °C

2.1: sulfuric acid / 120 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.bmc.2020.115509

Reference yield:

ethyl 2-cyano-2-(4-(tert-butyl)phenyl)acetate → (RS)-2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate (400882-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 120 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.bmc.2020.115509

upstream raw materials:

2-methoxyethyl 2-cyano-2-(4-(tert-butyl)phenyl)acetate

2-trifluoromethylbenzoyl chloride

4-tert-butylbenzyl cyanide

Refernces

• 1、 -. "Acylacetonitriles, process for preparation thereof and miticides containing the same". Page/Page column 7. . Retrieved 2008/06/13.