3288-99-1

Basic information

• Product Name: 4-tert-Butylphenyl-acetonitrile
• Synonyms: 4-(1,1-dimethylethyl)-benzeneacetonitril;4-TERT-BUTYLPHENYLACETONITRILE;4-TERT-BUTYL BENZYL CYANIDE;Butylphenylacetonitrile;HiCrome?MS.0157 Agar;4-Butylphenylacetonitrile;4-tert-Butylphenyl-acetonitril;2-[4-(tert-Butyl)phenyl]ethanenitrile
• CAS NO: 3288-99-1
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.25
• EINECS: 221-944-1
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Aromatic Nitriles;Organics
• Mol File: 3288-99-1.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 79-81°C 0,1mm
• Flash Point: 120.4 °C
• Appearance: /
• Density: 0.95 g/cm³
• Vapor Pressure: 0.00665mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-tert-Butylphenyl-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Butylphenyl-acetonitrile(3288-99-1)
• EPA Substance Registry System: 4-tert-Butylphenyl-acetonitrile(3288-99-1)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• Hazardous Substances Data: 3288-99-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C12H15N/c1-12(2,3)11-6-4-10(5-7-11)8-9-13/h4-7H,8H2,1-3H3

Upstream product

• 26537-19-9 methyl 4-tert-butylbenzoate 
• 13361-30-3 isopropyl cyanoacetate 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 105-34-0 methyl 2-cyanoacetate 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 372-09-8 cyanoacetic acid 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 19692-45-6 4-tert-butylbenzyl chloride 
• 1058648-68-2 4-tert-butyl-1-(methoxymethoxy)methyl benzene 
• 10442-39-4 tetra-n-butylammonium cyanide 

Downstream Products

• 157592-45-5 (4-tert-butylphenyl)(pyridin-2-yl)methanone 
• 154777-40-9 2-(4-t-butylphenyl)-2-(cyclohex-2-enyl)ethylamine 
• 855389-83-2 4-(4-tert-butyl-phenyl)-pyrrolidine-2,3,5-trione 
• 100368-57-8 2-(4-(tert-butyl)phenyl)acetamide 
• 1016534-37-4 2-(4-(tert-butyl)phenyl)ethanethioamide 
• 154777-56-7 2-(4-t-butylphenyl)-2-(cyclohex-2-enyl)acetonitrile 
• 73312-12-6 4-(4-tert-Butyl-phenyl)-4-cyano-heptanedioic acid dimethyl ester 
• 74788-90-2 2-(4-tert-Butyl-phenyl)-4-diisopropylamino-butyronitrile 
• 139512-41-7 dimethyl 2-methyl-2-(4-tert-butylphenyl)malonate 
• 101287-62-1 3-(4-tert-butyl-phenyl)-3-cyano-2-oxo-propionic acid ethyl ester 
• 320342-96-9 2-(4-(tert-butyl)phenyl)-3-phenylpropanamide 
• 1394973-40-0 benzo[d]thiazol-2-yl(4-(tert-butyl)phenyl)methanone 

Relevant articles and documents

Synthesis method of acaricide cyflumetofen intermediate p-tert-butyl phenylacetonitrile

The invention discloses a synthesis method of an acaricide cyflumetofen intermediate p-tert-butyl phenylacetonitrile, and belongs to the field of pesticide preparation. The synthesis method is characterized in that a reaction is performed on 4-tert-butyl

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Two-step cyanomethylation protocol: Convenient access to functionalized aryl- and heteroarylacetonitriles

A two-step protocol has been developed for the introduction of cyanomethylene groups to metalated aromatics through the intermediacy of substituted isoxazoles. A palladium-mediated cross-coupling reaction was used to introduce the isoxazole unit, followed by release of the cyanomethylene function under thermal or microwave-assisted conditions. The intermediate isoxazoles were shown to be amenable to further functionalization prior to deprotection of the sensitive cyanomethylene motif, allowing access to a wide range of aryl- and heteroaryl-substituted acetonitrile building blocks.